Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404945 | 0.90 | SLC6A4 (0.41) | SMN1; SMN2MEN1KMT2ANPSR1KDM4E | |
| SCHEMBL9404938 | 0.86 | CCNE2 (0.42) | MEN1KMT2AKDM4ELMNAALDH1A1 | |
| SCHEMBL28540861 | 0.69 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2ANPSR1KDM4E | |
| SCHEMBL28540860 | 0.69 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2ANPSR1KDM4E | |
| SCHEMBL841941 | 0.68 | TAAR1 (0.34) | LMNAALDH1A1MAPK1 | |
| SCHEMBL8090683 | 0.66 | GAA (0.63) | SMN1; SMN2MEN1KMT2ANPSR1KDM4E | |
| SCHEMBL25490757 | 0.65 | TSHR (0.43) | SMN1; SMN2MEN1KMT2AKDM4EL3MBTL1 | |
| SCHEMBL10315775 | 0.65 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2ANPSR1KDM4E | |
| SCHEMBL8254526 | 0.65 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2ANPSR1KDM4E | |
| SCHEMBL8259486 | 0.65 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2ANPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400916-B1 | 4,5,6,11-Tetrahydrobenzo [6,7]-cycloocta[1,2-b]thiophen-6,11-imines and 6,11-dihydrobenzo[6,7]-cycloocta[1,2-b]thiophen-6,11 imines | PFIZER (US) | 1994-11-09 | — | — | EP | disclosed |
| US-5260309-A | 4,5,6,11-tetrahydrobenzo [6,7] cycloocta [1,2-b]thiophen-6,11-imines and 6,11-dihydrobenzo [6,7] cycloocta [1,2-b] thiophen-6,11-imines | PFIZER INC. (US) | 1993-11-09 | — | — | US | disclosed |
| WO-1990015060-A1 | 4,5,6,11-TETRAHYDROBENZO[6,7]CYCLOOCTA[1,2-b]THIOPHEN-6,11-IMINES AND 6,11-DIHYDROBENZO[6,7]CYCLOOCTA[1,2-b]THIOPHEN-6,11-IMINES | PFIZER INC. (US) | 1990-12-13 | — | — | WO | disclosed |
| EP-0400916-A2 | 4,5,6,11-Tetrahydrobenzo [6,7]-cycloocta[1,2-b]thiophen-6,11-imines and 6,11-dihydrobenzo[6,7]-cycloocta[1,2-b]thiophen-6,11 imines | PFIZER INC. (US) | 1990-12-05 | — | — | EP | disclosed |