Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | CSNK2A3 | Q8NEV1 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31177224 | 1.00 | TP53 (0.53) | TP53HPGDTSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL16555392 | 0.90 | SMN1; SMN2 (0.56) | TP53HPGDTSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL22463118 | 0.84 | TDP1 (0.40) | TP53HPGDTSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL7653325 | 0.82 | BRD4 (0.39) | TP53HPGDTSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL7659144 | 0.81 | MAPT (0.46) | TP53HPGDTSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL4846663 | 0.81 | KDM4E (0.41) | TP53HPGDTSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL7656644 | 0.81 | HIF1A (0.41) | TP53HPGDTSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL29375067 | 0.81 | KDM4E (0.41) | TP53HPGDTSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL30841549 | 0.81 | HIF1A (0.41) | TP53HPGDTSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL27913623 | 0.79 | BRD4 (0.44) | SMN1; SMN2MAPTCSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296597-B1 | Hexa-cyclic compound | DAIICHI SEIYAKU CO (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5061795-A | ANTITUMOR AGENTS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-4939255-A | Hexa-cyclic camptothecin derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| EP-0296597-A2 | Hexa-cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1988-12-28 | — | — | EP | disclosed |