Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28182819 | 0.83 | MEN1 (0.56) | VCAM1MEN1KMT2AHSD17B10POLB | |
| SCHEMBL4361693 | 0.80 | HSD17B10 (0.60) | VCAM1MEN1KMT2AHSD17B10POLB | |
| SCHEMBL8245369 | 0.77 | KAT2B (0.56) | MEN1KMT2AHSD17B10POLBPDK1 | |
| SCHEMBL113357 | 0.77 | KMT2A (0.61) | MEN1KMT2AHSD17B10POLBPDK1 | |
| SCHEMBL9404937 | 0.76 | MEN1 (0.56) | MEN1KMT2AHSD17B10POLBPDK1 | |
| SCHEMBL9213419 | 0.75 | HSD17B10 (0.57) | MEN1KMT2AHSD17B10POLBALDH1A1 | |
| SCHEMBL10891727 | 0.74 | MEN1 (0.48) | MEN1KMT2AHSD17B10POLBPDK1 | |
| SCHEMBL5462968 | 0.74 | HSD17B10 (0.56) | VCAM1MEN1KMT2AHSD17B10POLB | |
| SCHEMBL5462964 | 0.74 | HSD17B10 (0.56) | VCAM1MEN1KMT2AHSD17B10POLB | |
| SCHEMBL5516694 | 0.74 | MAPT (0.69) | MEN1KMT2AHSD17B10POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296597-B1 | Hexa-cyclic compound | DAIICHI SEIYAKU CO (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5061795-A | ANTITUMOR AGENTS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-4939255-A | Hexa-cyclic camptothecin derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| EP-0296597-A2 | Hexa-cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1988-12-28 | — | — | EP | disclosed |