Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9409726 | 0.81 | GAA (0.45) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9409699 | 0.80 | CHRM2 (0.52) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL1342931 | 0.66 | KMT2A (0.37) | CHRM2CHRM1CYP2D6 | |
| SCHEMBL1342928 | 0.66 | KMT2A (0.37) | CHRM2CHRM1CYP2D6 | |
| SCHEMBL1344060 | 0.66 | KMT2A (0.37) | CHRM2CHRM1CYP2D6 | |
| SCHEMBL9022489 | 0.65 | CHRM2 (0.67) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9195859 | 0.65 | CHRM2 (0.60) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9195861 | 0.65 | CHRM2 (0.60) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10394829 | 0.65 | CHRM2 (0.60) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9022485 | 0.65 | CHRM2 (0.67) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0605393-A1 | Heterocyclic acetylenic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1994-07-06 | — | — | EP | disclosed |
| US-5225567-A | HETEROCYCLIC ACETYLENIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5157124-A | Improving mental performance | THE UPJOHN COMPANY (US) | 1992-10-20 | — | — | US | disclosed |
| US-5137905-A | Cholinergic agonists; analgesics; cognition activators | THE UPJOHN COMPANY (US) | 1992-08-11 | — | — | US | disclosed |
| WO-1990004588-A1 | HETEROCYCLIC ACETYLENIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-05-03 | — | — | WO | disclosed |