Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 17/20 | 0.38 |
| ▸ | PIP4K2C | Q8TBX8 | 14/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856379 | 0.82 | TSHR (0.36) | HTTPIP4K2CPAX8TSHRMEN1 | |
| SCHEMBL8856157 | 0.80 | SOAT1 (0.30) | — | |
| SCHEMBL8856912 | 0.80 | — | — | |
| SCHEMBL8856312 | 0.80 | PRSS1 (0.33) | TSHRMEN1TP53KMT2ALMNA | |
| SCHEMBL8856075 | 0.80 | PAK1 (0.34) | — | |
| SCHEMBL8856571 | 0.79 | CDC7 (0.36) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL8856450 | 0.76 | — | — | |
| SCHEMBL8856281 | 0.76 | — | — | |
| SCHEMBL8856080 | 0.73 | CYP1A2 (0.30) | TSHR | |
| SCHEMBL8856626 | 0.72 | SOAT1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0609960-A1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER INC. (US) | 1994-08-10 | — | — | EP | disclosed |
| EP-0418071-A2 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER INC. (US) | 1991-03-20 | — | — | EP | disclosed |