Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 2/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | UBE2N | P61088 | 1/20 | 0.61 |
| ▸ | F2 | P00734 | 1/20 | 0.60 |
| ▸ | F10 | P00742 | 1/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.60 |
| ▸ | F7 | P08709 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9416543 | 1.00 | SMPD1 (0.70) | SMPD1HDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL25769813 | 0.88 | NPC1 (0.62) | SMPD1HDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL25289002 | 0.87 | HPGD (0.64) | SMPD1HDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL28859140 | 0.86 | NR1H4 (0.82) | SMN1; SMN2NR1H4NPC1RAB9ALMNA | |
| SCHEMBL29430217 | 0.85 | SMN1; SMN2 (0.61) | SMPD1HDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL25240109 | 0.85 | SMN1; SMN2 (0.61) | SMPD1HDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL13491453 | 0.85 | MAPT (0.57) | SMPD1HDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL582322 | 0.84 | SMN1; SMN2 (0.85) | SMN1; SMN2NR1H4LMNAROCK2L3MBTL1 | |
| SCHEMBL28033750 | 0.83 | SMPD1 (0.73) | SMPD1HDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL24077087 | 0.83 | SMPD1 (0.72) | SMPD1HDAC1HDAC8HDAC6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613879-A1 | PHELLODENDRINE ANALOGS AND ALLERGY TYPE IV SUPPRESSOR CONTAINING THE SAME AS ACTIVE INGREDIENT | TSUMURA & CO. (JP) | 1994-09-07 | — | — | EP | disclosed |