Sugi Predict

Sugi Predict / Compounds / SCHEMBL9417243

SCHEMBL9417243

SCHEMBL9417243

O=C1OCCC1Oc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 1/20 0.47
▸ CRBN Q96SW2 1/20 0.47
▸ KDM4E B2RXH2 4/20 0.46
▸ CYP1A2 P05177 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ POLB P06746 3/20 0.41
▸ ALDH1A1 P00352 3/20 0.41
▸ HPGD P15428 3/20 0.41
▸ MAPT P10636 2/20 0.41
▸ GAA P10253 2/20 0.41
▸ TSHR P16473 1/20 0.40
▸ SLC6A2 P23975 1/20 0.40
▸ SLC6A3 Q01959 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ HRH1 P35367 1/20 0.39
▸ CTSV O60911 1/20 0.39
▸ CTSL P07711 1/20 0.39
▸ CTSB P07858 1/20 0.39
▸ CTSH P09668 1/20 0.39
▸ CTSS P25774 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13131095 0.87 KDM4E (0.40) DDB1CRBNKDM4ECYP1A2CYP2C19
SCHEMBL13131079 0.86 KDM4E (0.39) DDB1CRBNKDM4ECYP1A2CYP2C19
SCHEMBL12996674 0.86 KDM4E (0.39) DDB1CRBNKDM4ECYP1A2CYP2C19
SCHEMBL13163278 0.86 SMN1; SMN2 (0.46) DDB1CRBNKDM4ECYP1A2CYP2C19
SCHEMBL13163206 0.82 KDM4E (0.37) DDB1CRBNKDM4ECYP1A2CYP2C19
SCHEMBL23183007 0.82 KDM4E (0.40) KDM4ECYP1A2CYP2C19POLBALDH1A1
SCHEMBL13131163 0.82 POLB (0.38) KDM4EPOLBALDH1A1HPGDTSHR
SCHEMBL694533 0.82 POLB (0.41) KDM4ECYP1A2CYP2C19POLBALDH1A1
SCHEMBL10174373 0.82 SMN1; SMN2 (0.43) KDM4ECYP1A2CYP2C19POLBALDH1A1
SCHEMBL877644 0.82 KDM4E (0.41) KDM4EPOLBALDH1A1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114106046-B Oxazoline ring 5-substituted chiral spiro oxazoline-amino phosphine ligand, preparation method and application thereof 浙江九洲药业股份有限公司 2025-03-11 — — CN disclosed
US-11376260-B2 Serine/threonine kinase inhibitors GENENTECH, INC. (US) 2022-07-05 — — US disclosed
CN-114106046-A Oxazoline ring 5-substituted chiral spiro oxazoline-aminophosphine ligand and preparation method and application thereof 浙江九洲药业股份有限公司 2022-03-01 — — CN disclosed
US-20210106593-A1 SERINE/THREONINE KINASE INHIBITORS GENENTECH, INC. (US) 2021-04-15 — — US disclosed
US-10842799-B2 Serine/threonine kinase inhibitors GENENTECH, INC. (US) 2020-11-24 — — US disclosed
US-20200078371-A1 SERINE/THREONINE KINASE INHIBITORS GENENTECH, INC. (US) 2020-03-12 — — US disclosed
US-20190192534-A1 SERINE/THREONINE KINASE INHIBITORS GENENTECH, INC. (US) 2019-06-27 — — US disclosed
US-10278975-B2 Serine/threonine kinase inhibitors GENENTECH, INC. (US) 2019-05-07 — — US disclosed
EP-3077401-B1 SERINE/THREONINE KINASE INHIBITORS GENENTECH INC (US) 2018-04-18 — — EP disclosed
US-9867833-B2 Serine/threonine kinase inhibitors GENENTECH, INC. (US) 2018-01-16 — — US disclosed
US-20070148592-A1 Photosensitive composition, pattern-forming method using the photosensitive composition and compounds used in the photosensitive composition FUJIFILM CORPORATION (JP) 2007-06-28 — — US disclosed
EP-0229667-B1 Peptidylaminodiols ABBOTT LAB (US) 1994-07-13 — — EP disclosed
US-5032577-A Hypotensive ABBOTT LABORATORIES (US) 1991-07-16 — — US disclosed
EP-0295294-A4 PEPTIDYLAMINODIOLS. ABBOTT LAB (US) 1990-04-10 — — EP disclosed
US-4845079-A HYPOTENSIVE, RENIN INHIBITION ABBOTT LABORATORIES 1989-07-04 — — US disclosed
EP-0295294-A1 PEPTIDYLAMINODIOLS ABBOTT LABORATORIES (US) 1988-12-21 — — EP disclosed
WO-1988005050-A1 PEPTIDYLAMINODIOLS ABBOTT LABORATORIES (US) 1988-07-14 — — WO disclosed
EP-0229667-A2 Peptidylaminodiols ABBOTT LABORATORIES (US) 1987-07-22 — — EP disclosed
US-4178380-A LIPOGENSIS INHIBITORS SHELL OIL COMPANY (US) 1979-12-11 — — US disclosed
US-4103021-A BENZODIOXIN AND BENZOPYRAN CARBOXAMIDES SHELL OIL COMPANY (US) 1978-07-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11376260-B2 Serine/threonine kinase inhibitors MAP3K1, MAP3K4, MAP4K2 DDB1 762/4885CRBN 1568/4885KDM4E 1621/4885
US-10842799-B2 Serine/threonine kinase inhibitors MAP3K1, MAP3K4, MAP4K2 DDB1 762/4885CRBN 1568/4885KDM4E 1621/4885
US-10278975-B2 Serine/threonine kinase inhibitors MAP3K1, MAP3K4, MAP4K2 DDB1 762/4885CRBN 1568/4885KDM4E 1621/4885
US-20190192534-A1 SERINE/THREONINE KINASE INHIBITORS MAP3K1, MAP3K4, MAP4K2 DDB1 762/4885CRBN 1568/4885KDM4E 1621/4885
US-20210106593-A1 SERINE/THREONINE KINASE INHIBITORS MAP3K1, MAP3K4, MAP4K2 DDB1 762/4885CRBN 1568/4885KDM4E 1621/4885
US-20200078371-A1 SERINE/THREONINE KINASE INHIBITORS MAP3K1, MAP3K4, MAP4K2 DDB1 762/4885CRBN 1568/4885KDM4E 1621/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.