Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 5/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932822 | 0.83 | ADORA2A (0.46) | ADORA2AADORA1FGFR1SLC22A6PI4KA | |
| SCHEMBL29391225 | 0.81 | FGFR1 (0.68) | ADORA2AADORA1FGFR1SLC22A6ENPP1 | |
| SCHEMBL2107417 | 0.81 | FGFR1 (0.68) | ADORA2AADORA1FGFR1SLC22A6ENPP1 | |
| SCHEMBL3922476 | 0.80 | ADORA2A (0.50) | ADORA2AADORA1FGFR1SLC22A6PI4KA | |
| SCHEMBL27818519 | 0.80 | ADORA2A (0.50) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL1920120 | 0.80 | FGFR1 (0.67) | ADORA2AADORA1FGFR1SLC22A6NSD2 | |
| SCHEMBL4298072 | 0.79 | ADORA2A (0.56) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL9417160 | 0.77 | SLC22A6 (0.50) | ADORA2AADORA1FGFR1SLC22A6PI4KA | |
| SCHEMBL23834271 | 0.75 | ADORA2A (0.58) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL27455290 | 0.75 | ADORA2A (0.49) | ADORA2AADORA1PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319228-B1 | Novel compounds | BEECHAM GROUP PLC (GB) | 1994-11-02 | — | — | EP | disclosed |
| EP-0319228-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1989-06-07 | — | — | EP | disclosed |