Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL2588435 | 0.78 | TSHR (0.36) | CYP3A4TSHRNFKB1NPSR1CA2 | |
| Ammonia Solution, Strong SCHEMBL9569011 | 0.78 | CYP3A4 (0.32) | CYP3A4TSHRNFKB1NPSR1CA2 | |
| SCHEMBL1427298 | 0.77 | POLB (0.50) | CYP3A4TSHRNFKB1NPSR1CA2 | |
| SCHEMBL10913359 | 0.76 | MCL1 (0.32) | CYP3A4TSHRNFKB1NPSR1ALPL | |
| Ammonia Solution, Strong SCHEMBL6512029 | 0.76 | TSHR (0.34) | CYP3A4TSHRNFKB1NPSR1CA2 | |
| Hydrochloric Acid SCHEMBL25181737 | 0.75 | POLB (0.48) | CYP3A4TSHRNFKB1NPSR1CA2 | |
| SCHEMBL5322694 | 0.73 | CYP3A4 (0.32) | CYP3A4TSHRNFKB1NPSR1CA2 | |
| Acetic Acid SCHEMBL3682296 | 0.71 | POLB (0.50) | CYP3A4TSHRNFKB1NPSR1CA2 | |
| Acetic Acid SCHEMBL320011 | 0.70 | CA1 (0.40) | CYP3A4TSHRNFKB1NPSR1CA2 | |
| SCHEMBL15610744 | 0.65 | CHRM1 (0.33) | TSHRCA2ALPLPOLBALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373095-A | Steroid compounds | THE UPJOHN COMPANY (US) | 1994-12-13 | — | — | US | disclosed |
| US-5334712-A | Estrane or androstane pyridinyl alkyl or alkylphenyl amine steroids for antidiabetes and obesity | THE UPJOHN COMPANY (US) | 1994-08-02 | — | — | US | disclosed |
| US-5274089-A | A estra-1,3,5(10)-triene derivative | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| US-5196542-A | Phospholipase A2 inhibitors | THE UPJOHN COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| US-5187299-A | Phospholipase inhibitors; treating diabetes, obesity | THE UPJOHN COMPANY (US) | 1993-02-16 | — | — | US | disclosed |
| US-5145874-A | Phospholipase inhibitor, hypoglycemic agent, antidiabetic, obesity | THE UPJOHN COMPANY (US) | 1992-09-08 | — | — | US | disclosed |
| US-4917826-A | TREATING DIABETES AND OBESITY | THE UPJOHN COMPANY (US) | 1990-04-17 | — | — | US | disclosed |