Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10805903 | 0.81 | ESR1 (0.35) | ESR1ESR2CYP19A1 | |
| SCHEMBL10565611 | 0.76 | ESR1 (0.47) | LMNAESR1ESR2CYP19A1MEN1 | |
| SCHEMBL10639909 | 0.73 | ESR1 (0.35) | LMNAESR1ESR2CYP19A1MEN1 | |
| SCHEMBL10630224 | 0.73 | STS (0.40) | KDM4ELMNAESR1ESR2 | |
| SCHEMBL9418224 | 0.72 | ESR1 (0.69) | ESR1ESR2 | |
| SCHEMBL10977119 | 0.71 | STS (0.41) | ESR1ESR2CYP19A1 | |
| SCHEMBL7379616 | 0.70 | TRPV1 (0.76) | HPGDKDM4ELMNATRPV1GAA | |
| SCHEMBL10640037 | 0.70 | ESR1 (0.36) | ESR1ESR2CYP19A1 | |
| SCHEMBL14569854 | 0.70 | ESR1 (0.54) | LMNAESR1ESR2MEN1KMT2A | |
| SCHEMBL10641435 | 0.70 | STS (0.41) | KDM4ELMNAESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0346014-B1 | Therapeutic product for the treatment of peri- or postmenopausal conditions | ZENECA LTD (GB) | 1994-08-03 | — | — | EP | disclosed |