Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | P2RX4 | Q99571 | 14/20 | 0.54 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrrolidine SCHEMBL9419619 | 0.98 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTNPSR1P2RX4P2RX1 | |
| Piperidine SCHEMBL6045374 | 0.89 | MAPT (0.54) | SMN1; SMN2MAPTNPSR1P2RX4 | |
| Pyrrolidine SCHEMBL6045325 | 0.87 | MAPT (0.55) | SMN1; SMN2MAPTNPSR1P2RX4 | |
| Morpholine SCHEMBL9419653 | 0.87 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTNPSR1P2RX4P2RX1 | |
| SCHEMBL3451033 | 0.85 | SMN1; SMN2 (0.75) | SMN1; SMN2MAPTNPSR1P2RX4P2RX1 | |
| Morpholine SCHEMBL6045317 | 0.77 | MAPT (0.53) | SMN1; SMN2MAPTNPSR1P2RX4 | |
| SCHEMBL5242441 | 0.73 | MAPT (0.67) | SMN1; SMN2MAPTNPSR1P2RX4P2RX1 | |
| SCHEMBL17086908 | 0.73 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTNPSR1P2RX4P2RX1 | |
| SCHEMBL25189857 | 0.71 | MAPT (0.56) | SMN1; SMN2MAPTNPSR1P2RX4P2RX1 | |
| SCHEMBL5126303 | 0.70 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTNPSR1P2RX4P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371081-A | Useful in potentiating the cytotoxic effect of chemotherapeutic agents | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 1994-12-06 | — | — | US | claimed |
| WO-1993003729-A1 | N-SUBSTITUTED PHENOXAZINES FOR TREATING MULTIDRUG RESISTANT CANCER CELLS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | claimed |
| US-5371081-A | Useful in potentiating the cytotoxic effect of chemotherapeutic agents | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 1994-12-06 | — | — | US | disclosed |
| WO-1993003729-A1 | N-SUBSTITUTED PHENOXAZINES FOR TREATING MULTIDRUG RESISTANT CANCER CELLS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | disclosed |