Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 13/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 11/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL942519 | 0.95 | EGLN1 (0.50) | EGLN1EGLN3EGLN2MEN1KMT2A | |
| SCHEMBL941916 | 0.94 | EGLN1 (0.44) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL12913748 | 0.92 | EGLN1 (0.42) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL942545 | 0.91 | EGLN1 (0.44) | EGLN1EGLN3EGLN2MEN1KMT2A | |
| SCHEMBL941689 | 0.91 | EGLN1 (0.41) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL942339 | 0.90 | EGLN1 (0.50) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL12913755 | 0.90 | EGLN1 (0.42) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL942988 | 0.89 | EGLN1 (0.41) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL941964 | 0.89 | EGLN1 (0.49) | EGLN1EGLN3EGLN2CYSLTR2 | |
| Trifluoroacetic Acid SCHEMBL941015 | 0.88 | EGLN1 (0.44) | EGLN1EGLN3EGLN2CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257171-B1 | TETRAHYDRO-1H-PYRROLO-FUSED PYRIDONES | MERCK SHARP & DOHME (US) | 2016-02-10 | — | — | EP | claimed |
| US-8372863-B2 | Tetrahydro-1H-pyrrolo fused pyridones | MERCK SHARP & DOHME CORP. (US) | 2013-02-12 | — | — | US | claimed |
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | MERCK SHARP & DOHME LLC | 2011-01-13 | — | — | US | claimed |
| EP-2257171-B1 | TETRAHYDRO-1H-PYRROLO-FUSED PYRIDONES | MERCK SHARP & DOHME (US) | 2016-02-10 | — | — | EP | disclosed |
| US-8372863-B2 | Tetrahydro-1H-pyrrolo fused pyridones | MERCK SHARP & DOHME CORP. (US) | 2013-02-12 | — | — | US | disclosed |
| US-8372863-B2 | Tetrahydro-1H-pyrrolo fused pyridones | MERCK SHARP & DOHME CORP. (US) | 2013-02-12 | — | — | US | disclosed |
| US-8372863-B2 | Tetrahydro-1H-pyrrolo fused pyridones | MERCK SHARP & DOHME CORP. (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | MERCK SHARP & DOHME LLC | 2011-01-13 | — | — | US | disclosed |
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | MERCK SHARP & DOHME LLC | 2011-01-13 | — | — | US | disclosed |
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | MERCK SHARP & DOHME LLC | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | HIF1AN, EGLN2, EGLN3 | EGLN1 7/4885EGLN3 3/4885EGLN2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.