SCHEMBL9420787

SCHEMBL9420787

CC(C)(C)OC(=O)CC(O)CC(O)/C=C/c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 3/20 0.37
SIRT6 Q8N6T7 2/20 0.37
HMGCR P04035 2/20 0.37
ABCC3 O15438 1/20 0.37
ABCB11 O95342 1/20 0.37
PGR P06401 1/20 0.37
ADORA3 P0DMS8 1/20 0.37
RXRA P19793 1/20 0.37
TBXA2R P21731 1/20 0.37
CCKAR P32238 1/20 0.37
ADRA1A P35348 1/20 0.37
PTGS2 P35354 1/20 0.37
NR4A2 P43354 1/20 0.37
PDE4D Q08499 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9420790 1.00 HDAC3 (0.40) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL9420672 0.85 CNR2 (0.40) CYP1A2
SCHEMBL9420668 0.85 CNR2 (0.40) CYP1A2
SCHEMBL10764722 0.84 CYP4F2 (0.44) ADORA3
SCHEMBL11283691 0.84 CYP4F2 (0.44) ADORA3
SCHEMBL9420680 0.82 HDAC3 (0.40) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL9420682 0.82 HDAC3 (0.40) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL9114469 0.80 CYP2C9 (0.47) CYP1A2CYP2C9SIRT6HMGCRABCC3
SCHEMBL9114479 0.80 CYP2C9 (0.47) CYP1A2CYP2C9SIRT6HMGCRABCC3
SCHEMBL9114307 0.80 CYP2C9 (0.47) CYP1A2CYP2C9SIRT6HMGCRABCC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5347039-A Process for the preparation of derivatives of 3,5-dihydroxypentanoic acid RHONE-POULENC RORER S.A. (FR) 1994-09-13 US disclosed
US-5070206-A INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; ANTICHOLESTEROL, ANTILIPEMIC BRISTOL-MYERS COMPANY (US) 1991-12-03 US disclosed
US-5011947-A Enzyme inhibitors for cholesterol biosythesis BRISTOL-MYERS (US) 1991-04-30 US disclosed
US-5010205-A Antihypercholesterolemic tetrazol-1-yl intermediates BRISTOL-MYERS COMPANY (US) 1991-04-23 US disclosed
EP-0355820-A1 Antihypercholesterolemic tetrazol-1-yl compounds Bristol-Myers Squibb Company (US) 1990-02-28 EP disclosed
US-4870187-A ANTILIPEMIC, ATHEROSCLEROSIS BRISTOL-MYERS COMPANY (US) 1989-09-26 US disclosed