Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.52 |
| ▸ | EGLN2 | Q96KS0 | 13/20 | 0.51 |
| ▸ | EGLN3 | Q9H6Z9 | 13/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14693378 | 0.94 | EGLN1 (0.60) | EGLN1EGLN2EGLN3CYSLTR2 | |
| Hydrochloric Acid SCHEMBL942345 | 0.93 | EGLN1 (0.59) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL942076 | 0.82 | EGLN1 (0.60) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL12913741 | 0.80 | EGLN1 (0.61) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL941364 | 0.78 | EGLN1 (0.63) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL944125 | 0.78 | EGLN1 (0.56) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL942422 | 0.77 | EGLN1 (0.72) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL941933 | 0.77 | EGLN1 (0.62) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL942313 | 0.77 | EGLN1 (0.62) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL941114 | 0.77 | EGLN1 (0.62) | EGLN1EGLN2EGLN3CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257171-B1 | TETRAHYDRO-1H-PYRROLO-FUSED PYRIDONES | MERCK SHARP & DOHME (US) | 2016-02-10 | — | — | EP | claimed |
| US-8372863-B2 | Tetrahydro-1H-pyrrolo fused pyridones | MERCK SHARP & DOHME CORP. (US) | 2013-02-12 | — | — | US | claimed |
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | MERCK SHARP & DOHME LLC | 2011-01-13 | — | — | US | claimed |
| EP-2257171-B1 | TETRAHYDRO-1H-PYRROLO-FUSED PYRIDONES | MERCK SHARP & DOHME (US) | 2016-02-10 | — | — | EP | disclosed |
| US-8372863-B2 | Tetrahydro-1H-pyrrolo fused pyridones | MERCK SHARP & DOHME CORP. (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | MERCK SHARP & DOHME LLC | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | HIF1AN, EGLN2, EGLN3 | EGLN1 7/4885EGLN2 2/4885EGLN3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.