Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9427147 | 0.99 | STAT3 (0.58) | STAT3KMT2AHTTADRB2KDM4E | |
| SCHEMBL10563399 | 0.92 | STAT3 (0.56) | STAT3KMT2AHTTADRB2KDM4E | |
| SCHEMBL9427246 | 0.87 | STAT3 (0.44) | STAT3KMT2AHTTADRB2KDM4E | |
| SCHEMBL9572075 | 0.87 | STAT3 (0.56) | STAT3KMT2AHTTADRB2KDM4E | |
| SCHEMBL13326857 | 0.86 | STAT3 (0.55) | STAT3KMT2AHTTADRB2KDM4E | |
| SCHEMBL9427319 | 0.85 | STAT3 (0.54) | STAT3KMT2AHTTADRB2KDM4E | |
| SCHEMBL10669008 | 0.85 | STAT3 (0.54) | STAT3KMT2AHTTADRB2KDM4E | |
| SCHEMBL9427095 | 0.85 | STAT3 (0.54) | STAT3KMT2AHTTADRB2KDM4E | |
| SCHEMBL3289292 | 0.85 | STAT3 (0.46) | STAT3KMT2AHTTADRB2KDM4E | |
| SCHEMBL13326853 | 0.83 | STAT3 (0.52) | STAT3KMT2AHTTADRB2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5359066-A | Certain tricyclic pyrido[3,2,1-ij]cinnoline-8-carboxylates, useful as antimicrobial agents | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-25 | — | — | US | disclosed |
| EP-0530368-A1 | PROCESS FOR PRODUCING TRICYCLIC COMPOUND OR SALT THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-10 | — | — | EP | disclosed |
| US-4977265-A | WITH BACTERICIDAL ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4946847-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4806541-A | ANTIBACTERIAL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-02-21 | — | — | US | disclosed |
| US-4753925-A | Antibacterial 1,7-diamino-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1988-06-28 | — | — | US | disclosed |