Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.48 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931308 | 0.84 | BACE1 (0.63) | BACE1KCNH2BACE2APP | |
| SCHEMBL932157 | 0.70 | BACE1 (0.51) | BACE1KCNH2BACE2 | |
| SCHEMBL7871272 | 0.68 | BACE1 (0.59) | BACE1KCNH2BACE2PTGES2 | |
| SCHEMBL931544 | 0.67 | BACE1 (0.66) | BACE1KCNH2BACE2APP | |
| Formic Acid SCHEMBL2286740 | 0.65 | BACE1 (0.55) | BACE1KCNH2BACE2PTGES2 | |
| SCHEMBL943175 | 0.65 | BACE1 (1.00) | BACE1KCNH2BACE2APP | |
| SCHEMBL931630 | 0.65 | BACE1 (0.61) | BACE1KCNH2BACE2APP | |
| SCHEMBL7865271 | 0.64 | BACE1 (0.64) | BACE1KCNH2BACE2 | |
| SCHEMBL30957059 | 0.63 | IDO1 (0.52) | BACE1KCNH2BACE2PTGES2 | |
| SCHEMBL29796762 | 0.63 | IDO1 (0.52) | BACE1KCNH2BACE2PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |