⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786274 | 0.79 | — | — | |
| SCHEMBL21500439 | 0.66 | — | — | |
| SCHEMBL2994409 | 0.65 | — | — | |
| SCHEMBL10425041 | 0.65 | — | — | |
| SCHEMBL105522 | 0.64 | — | — | |
| SCHEMBL17831046 | 0.61 | — | — | |
| SCHEMBL14080069 | 0.60 | — | — | |
| SCHEMBL17232939 | 0.59 | — | — | |
| SCHEMBL10050860 | 0.59 | — | — | |
| SCHEMBL3282121 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350038-B2 | Fluorescence quencher molecules | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2013-01-08 | — | — | US | claimed |
| EP-2336119-B1 | Fluorescent quencher molecules as well as methods and uses involving the same | HOFFMANN LA ROCHE (CH) | 2012-05-09 | — | — | EP | claimed |
| EP-2336119-A1 | Fluorescent quencher molecules as well as methods and uses involving the same | F. Hoffmann-La Roche AG (CH) | 2011-06-22 | — | — | EP | claimed |
| US-20110092689-A1 | FLUORESCENCE QUENCHER MOLECULES | ROCHE DIAGNOSTICS GMBH (DE) | 2011-04-21 | — | — | US | claimed |
| EP-1663238-B1 | HEXA- AND OCTAHYDRO-PYRIDO[1,2-a] PYRAZINE DERIVATIVES WITH NK1 ANTAGONISTIC ACTIVITY | SOLVAY PHARM BV (NL) | 2009-08-12 | — | — | EP | claimed |
| US-7244734-B2 | Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with NK1 antagonistic activity | SOLVAY PHARMACEUTICALS B.V. (NL) | 2007-07-17 | — | — | US | claimed |
| WO-2006013205-A1 | NEUROKININ-1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CONDITIONS RESPONSIVE TO TESTOSTERONE ELEVATION | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-02-09 | — | — | WO | claimed |
| US-20060030556-A1 | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation, including testosterone deficiency | SOLVAY PHARMACEUTICALS B.V. | 2006-02-09 | — | — | US | claimed |
| US-20050070548-A1 | Hexa-and octahydro-pyrido[1,2-a]pyrazine derivatives with NK1 antagonistic activity | SOLVAY PHARMACEUTICALS B.V. | 2005-03-31 | — | — | US | claimed |
| US-12637454-B2 | Heterocyclic monoacylglycerol lipase (MAGL) inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2026-05-26 | — | — | US | disclosed |
| US-12558329-B2 | Methods and compositions for treating 4-hydroxyphenylpyruvate dioxygenase-like (HPDL)-related diseases or disorders | NEW YORK UNIVERSITY (US) | 2026-02-24 | — | — | US | disclosed |
| US-20250320213-A1 | Nitrogen-Containing Heterocyclic Compounds | PFIZER INC. (US) | 2025-10-16 | — | — | US | disclosed |
| US-20250282762-A1 | PYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2025-09-11 | — | — | US | disclosed |
| US-20250213569-A1 | METHODS AND COMPOSITIONS FOR MEASURING AND INHIBITING EXONUCLEASE ACTIVITY | NEW YORK UNIVERSITY (US) | 2025-07-03 | — | — | US | disclosed |
| WO-1992000075-A1 | PYRIDOPYRAZINE DERIVATIVES FOR TREATING SUBSTANCE ABUSE AND ADDICTION | PFIZER INC. (US) | 1992-01-09 | — | — | WO | disclosed |
| WO-1992000074-A2 | PYRIDOPYRAZINE DERIVATIVES FOR TREATING SUBSTANCE ABUSE AND ADDICTION | PFIZER INC. (US) | 1992-01-09 | — | — | WO | disclosed |
| EP-0380217-A1 | Bis-aza-bicyclic anxiolytic agents and antidepressants | PFIZER INC. (US) | 1990-08-01 | — | — | EP | disclosed |
| WO-1990008148-A1 | BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS | PFIZER INC. (US) | 1990-07-26 | — | — | WO | disclosed |
| WO-1990008144-A1 | BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS | PFIZER INC. (US) | 1990-07-26 | — | — | WO | disclosed |
| US-4519937-A | DOPED UNITS OF A FUSED NITROGEN-CONTAINING UNSATURATED HETEROCYCLIC RING | CHEVRON RESEARCH COMPANY (US) | 1985-05-28 | — | — | US | disclosed |