Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | CCKBR | P32239 | 1/20 | 0.51 |
| ▸ | MC4R | P32245 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429908 | 0.93 | HTT (0.57) | HTTMAPTALDH1A1TP53LMNA | |
| SCHEMBL9429927 | 0.92 | HTT (0.56) | HTTMAPTALDH1A1TP53LMNA | |
| SCHEMBL9429695 | 0.91 | HTT (0.54) | HTTMAPTALDH1A1TP53LMNA | |
| SCHEMBL9429291 | 0.90 | HTT (0.53) | HTTMAPTALDH1A1TP53LMNA | |
| SCHEMBL9429840 | 0.90 | HTT (0.53) | HTTMAPTALDH1A1TP53LMNA | |
| SCHEMBL9428482 | 0.90 | HTT (0.54) | HTTMAPTALDH1A1TP53LMNA | |
| SCHEMBL9429138 | 0.89 | HTT (0.53) | HTTMAPTALDH1A1TP53LMNA | |
| SCHEMBL9429800 | 0.89 | HTT (0.53) | HTTMAPTALDH1A1TP53LMNA | |
| SCHEMBL9423132 | 0.88 | HTT (0.64) | HTTMAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL9429928 | 0.87 | HTT (0.53) | HTTMAPTALDH1A1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5310903-A | Autoimmune diseases; organ transplants; antitumor agnets; antiinflammatory agents; infections | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |