Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 4/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429136 | 0.90 | CYSLTR2 (0.51) | CYSLTR2CYSLTR1PTPN11LTB4RPLA2G4B | |
| SCHEMBL9427799 | 0.90 | PTPN11 (0.47) | CYSLTR2CYSLTR1PTPN11LTB4RPLA2G4B | |
| SCHEMBL9429208 | 0.90 | PTPN11 (0.47) | CYSLTR2CYSLTR1PTPN11LTB4RPLA2G4B | |
| SCHEMBL9428048 | 0.89 | PTPN11 (0.46) | CYSLTR2CYSLTR1PTPN11LTB4RPLA2G4B | |
| SCHEMBL9428261 | 0.89 | PTPN11 (0.46) | CYSLTR2CYSLTR1PTPN11LTB4RPLA2G4B | |
| SCHEMBL9428685 | 0.89 | PTPN11 (0.46) | CYSLTR2CYSLTR1PTPN11LTB4RPLA2G4B | |
| SCHEMBL9428953 | 0.89 | CYSLTR2 (0.52) | CYSLTR2CYSLTR1PTPN11LTB4RPLA2G4B | |
| SCHEMBL9428702 | 0.88 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1PTPN11LTB4RPLA2G4B | |
| SCHEMBL9428678 | 0.88 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1PTPN11LTB4RPLA2G4B | |
| SCHEMBL9428150 | 0.88 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1PTPN11LTB4RPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314918-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0296732-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-09 | — | — | EP | disclosed |
| EP-0296732-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1988-12-28 | — | — | EP | disclosed |