Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404419 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPK14KDM4EMAPK1HPGD | |
| SCHEMBL17565791 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EMAPK1HPGDPIK3CA | |
| SCHEMBL3718191 | 0.83 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EMAPK1HPGDPIK3CA | |
| SCHEMBL2726311 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4EMAPK1HPGDPIK3CA | |
| SCHEMBL8408287 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EHPGDPIK3CAPRKDC | |
| SCHEMBL2725465 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EHPGDPIK3CAPRKDC | |
| SCHEMBL2420833 | 0.80 | PRKDC (0.73) | SMN1; SMN2KDM4EMAPK1PIK3CAPRKDC | |
| SCHEMBL4095134 | 0.80 | KDM4E (0.69) | SMN1; SMN2KDM4EMAPK1HPGDLMNA | |
| SCHEMBL2726410 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPK14KDM4EMAPK1HPGD | |
| SCHEMBL2725541 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EMAPK1HPGDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |