Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.69 |
| ▸ | APP | P05067 | 3/20 | 0.67 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.66 |
| ▸ | GALR3 | O60755 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | CNR1 | P21554 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.63 |
| ▸ | AURKA | O14965 | 4/20 | 0.62 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.62 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | CDK7 | P50613 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6833289 | 0.82 | EGFR (1.00) | EGFRAPPCNR1LMNAAURKA | |
| SCHEMBL29386010 | 0.80 | EGFR (1.00) | EGFRAPPNR2F2GALR3RAB9A | |
| SCHEMBL7612718 | 0.80 | EGFR (1.00) | EGFRAPPNR2F2GALR3RAB9A | |
| SCHEMBL27990386 | 0.80 | EGFR (0.71) | EGFRAPPNR2F2GALR3RAB9A | |
| SCHEMBL8886913 | 0.80 | EGFR (0.72) | EGFRAPPNR2F2GALR3RAB9A | |
| SCHEMBL5113671 | 0.80 | APP (0.74) | EGFRAPPHTTLMNATSHR | |
| SCHEMBL17557541 | 0.79 | CNR1 (1.00) | CNR1 | |
| SCHEMBL13191861 | 0.79 | EGFR (0.58) | EGFRAPPNR2F2GALR3RAB9A | |
| SCHEMBL21567457 | 0.79 | PDE4A (0.67) | EGFRAPPCNR1LMNAMAPK1 | |
| SCHEMBL4866870 | 0.79 | APP (0.73) | EGFRAPPAURKACDK2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296484-A | Applying fungicide to locus of plant pathogen | DOWELANCO (US) | 1994-03-22 | — | — | US | disclosed |
| CN-1034924-A | quinoline, quinazoline and cinnoline derivatives | LILLY CO ELI (US) | 1989-08-23 | — | — | CN | disclosed |
| EP-0326328-A2 | Quinoline, quinazoline, and cinnoline derivatives | DowElanco (US) | 1989-08-02 | — | — | EP | disclosed |