SCHEMBL9430784

SCHEMBL9430784

CC(C)(C)[Si](C)(C)OCc1ccc2c(c1)Nc1ncccc1NC2=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
NPC1 O15118 1/20 0.40
ALDH1A1 P00352 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
RAB9A P51151 1/20 0.40
MCL1 Q07820 1/20 0.40
GSK3B P49841 4/20 0.37
MAP4K4 O95819 3/20 0.37
CDK2 P24941 3/20 0.37
CLK4 Q9HAZ1 3/20 0.37
CDC7 O00311 2/20 0.37
ROCK2 O75116 2/20 0.37
IRAK4 Q9NWZ3 2/20 0.37
MKNK2 Q9HBH9 1/20 0.37
CHEK1 O14757 5/20 0.35
PRKACA P17612 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5894301 0.74 SMN1; SMN2 (0.46) SMN1; SMN2ALDH1A1MAPTMAOAMAOB
SCHEMBL5894304 0.74 SMN1; SMN2 (0.46) SMN1; SMN2ALDH1A1MAPTMAOAMAOB
SCHEMBL9824523 0.73 CYP1A2 (0.70) CYP1A2SMN1; SMN2NPC1ALDH1A1GAA
SCHEMBL9430781 0.72 CYP1A2 (0.44) CYP1A2SMN1; SMN2NPC1ALDH1A1GAA
SCHEMBL9178466 0.71 CYP1A2 (0.56) CYP1A2SMN1; SMN2NPC1ALDH1A1GAA
SCHEMBL10391265 0.71 CYP1A2 (0.56) CYP1A2SMN1; SMN2NPC1ALDH1A1GAA
SCHEMBL10392137 0.71 CYP1A2 (0.56) CYP1A2SMN1; SMN2NPC1ALDH1A1GAA
SCHEMBL9824365 0.70 SMN1; SMN2 (0.52) CYP1A2SMN1; SMN2NPC1ALDH1A1GAA
SCHEMBL6747437 0.70 ICAM1 (0.55) SMN1; SMN2GAAMAPT
SCHEMBL2420515 0.70 CYP1A2 (0.77) CYP1A2SMN1; SMN2NPC1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5324832-A Muscarinic antagonists THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1994-06-28 US disclosed
WO-1993000906-A1 MUSCARINIC ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1993-01-21 WO disclosed