Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 13/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9434174 | 0.96 | SPHK1 (0.47) | SPHK1SPHK2CYP2C9CYP3A4CYP2C8 | |
| SCHEMBL9399591 | 0.94 | SPHK1 (0.50) | SPHK1SPHK2CYP2C9S1PR3 | |
| SCHEMBL9399734 | 0.93 | SPHK1 (0.43) | SPHK1SPHK2CYP2C9ALDH1A1LMNA | |
| SCHEMBL9398806 | 0.91 | SPHK1 (0.45) | SPHK1SPHK2CYP2C9CYP3A4MAPT | |
| SCHEMBL9398581 | 0.91 | SPHK1 (0.45) | SPHK1SPHK2CYP2C9CYP3A4MAPT | |
| SCHEMBL9398743 | 0.91 | SPHK1 (0.45) | SPHK1SPHK2CYP2C9CYP3A4MAPT | |
| SCHEMBL9398917 | 0.88 | HPGD (0.37) | SPHK1S1PR3ALDH1A1MAPT | |
| SCHEMBL19722327 | 0.87 | SPHK1 (0.40) | SPHK1SPHK2CYP2C9CYP3A4CYP2C8 | |
| SCHEMBL9399384 | 0.87 | SPHK1 (0.35) | SPHK1SPHK2CYP2C9CYP3A4CYP2C8 | |
| SCHEMBL9433861 | 0.87 | OPRL1 (0.38) | SPHK1CYP2C9CYP3A4CYP2C8CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5338483-A | Anisotropic compounds having nematic phase and liquid crystal mixtures | MERCK PATENT GMBH (DE) | 1994-08-16 | — | — | US | disclosed |
| US-5227484-A | ANISOTROPIC COMPOUNDS HAVING NEMATIC PHASE AND LIQUID CRYSTAL MIXTURES | MERCK PATENT GMBH (DE) | 1993-07-13 | — | — | US | disclosed |
| US-5179101-A | Anisotropic compounds having nematic phase and liquid crystal mixtures | MERCK PATENT GMBH (DE) | 1993-01-12 | — | — | US | disclosed |
| US-4808333-A | Anisotropic compounds having nematic phase and liquid crystal mixtures | MERCK PATENT GMBH (DE) | 1989-02-28 | — | — | US | disclosed |
| EP-0084194-B1 | LIQUID CRYSTAL MIXTURES | MERCK PATENT GmbH (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0084194-A1 | Liquid crystal mixtures | MERCK PATENT GmbH (DE) | 1983-07-27 | — | — | EP | disclosed |