Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.58 |
| ▸ | DRD4 | P21917 | 6/20 | 0.58 |
| ▸ | DRD2 | P14416 | 5/20 | 0.58 |
| ▸ | HRH2 | P25021 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | DRD5 | P21918 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043895 | 0.87 | MAPK1 (0.77) | MAPK1HRH4DRD4DRD2HRH2 | |
| SCHEMBL3254394 | 0.83 | MAPK1 (0.71) | MAPK1HRH4DRD4DRD2HRH2 | |
| SCHEMBL123132 | 0.83 | MAPK1 (0.71) | MAPK1HRH4DRD4DRD2HRH2 | |
| SCHEMBL1773258 | 0.81 | MAPK1 (0.67) | MAPK1HRH4DRD4DRD2HRH2 | |
| SCHEMBL9434561 | 0.80 | MAPK1 (0.67) | MAPK1HRH4DRD4DRD2HRH2 | |
| SCHEMBL9433516 | 0.78 | MAPK1 (0.63) | MAPK1HRH4DRD4DRD2HRH2 | |
| SCHEMBL11097808 | 0.77 | MAPK1 (0.62) | MAPK1HRH4DRD4DRD2HRH2 | |
| SCHEMBL11414467 | 0.75 | MAPK1 (0.59) | MAPK1HRH4DRD4DRD2HRH2 | |
| SCHEMBL12142524 | 0.74 | MAPK1 (0.59) | MAPK1HRH4DRD4DRD2HRH2 | |
| Iodide SCHEMBL11405476 | 0.74 | MAPK1 (0.58) | MAPK1HRH4DRD4DRD2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5324722-A | Analgesics | G. D. SEARLE & CO. (US) | 1994-06-28 | — | — | US | disclosed |
| WO-1993013082-A1 | SUBSTITUTED DIBENZOXAZEPINES OR DIBENZOTHIAZEPINES AND THEIR USE AS PROSTAGLANDIN E2 ANTAGONISTS | G.D. SEARLE & CO. (US) | 1993-07-08 | — | — | WO | disclosed |