Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29622965 | 0.84 | KDM4E (0.58) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29623104 | 0.82 | KDM4E (0.57) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL4551617 | 0.79 | KDM4E (0.67) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6466096 | 0.74 | RAF1 (0.68) | KMT2AALDH1A1KDM4EHPGDGAA | |
| SCHEMBL9666048 | 0.74 | MAPK13 (0.49) | SMN1; SMN2L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL19868852 | 0.73 | MAPK11 (0.70) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL15676771 | 0.73 | SMN1; SMN2 (0.55) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL28483060 | 0.72 | KMT2A (0.56) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL3818831 | 0.71 | SMN1; SMN2 (1.00) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL10726628 | 0.71 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231622-B1 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORP (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0231622-A2 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-12 | — | — | EP | disclosed |
| US-4263311-A | ANTIARTHRITIC AGENTS | SMITHKLINE CORPORATION (US) | 1981-04-21 | — | — | US | disclosed |