Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.71 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL9436026 | 1.00 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| Hydrochloric Acid SCHEMBL11369989 | 0.88 | TDP1 (0.87) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL11403139 | 0.87 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| Methylethylamine SCHEMBL11375480 | 0.85 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL7378916 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL146947 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| Ethylamine SCHEMBL11381979 | 0.83 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL9435577 | 0.82 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL9435904 | 0.82 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| Diethylamine SCHEMBL9435597 | 0.82 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231622-B1 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORP (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0231622-A2 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-12 | — | — | EP | disclosed |