Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MDM4 | O15151 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966500 | 0.89 | HDAC1 (0.63) | HDAC1HDAC6PARP1PARP3ATM | |
| SCHEMBL4145476 | 0.89 | HDAC1 (0.63) | HDAC1HDAC6PARP1PARP3ATM | |
| SCHEMBL4145473 | 0.89 | HDAC1 (0.63) | HDAC1HDAC6PARP1PARP3ATM | |
| SCHEMBL9556174 | 0.88 | HDAC1 (0.53) | HDAC1HDAC6PARP1PARP3ATM | |
| SCHEMBL4153061 | 0.85 | MDM4 (0.67) | HDAC1HDAC6PARP1PARP3ATM | |
| SCHEMBL4149820 | 0.85 | MDM4 (0.67) | HDAC1HDAC6PARP1PARP3ATM | |
| SCHEMBL4149824 | 0.85 | MDM4 (0.67) | HDAC1HDAC6PARP1PARP3ATM | |
| SCHEMBL4153058 | 0.85 | MDM4 (0.67) | HDAC1HDAC6PARP1PARP3ATM | |
| SCHEMBL9440111 | 0.84 | HDAC1 (0.59) | HDAC1HDAC6PARP1PARP3ATM | |
| SCHEMBL9440106 | 0.84 | HDAC1 (0.59) | HDAC1HDAC6PARP1PARP3ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526488-B1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS | PFIZER (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5326905-A | Benzylphosphonic acid tyrosine kinase inhibitors | PFIZER INC. (US) | 1994-07-05 | — | — | US | disclosed |
| WO-1991015495-A1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |