Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.32 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL508167 | 0.83 | HPGD (0.53) | HPGDTSHRMEN1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL507244 | 0.82 | HPGD (0.52) | HPGDTSHRMEN1ALDH1A1TP53 | |
| SCHEMBL9440408 | 0.81 | HPGD (0.54) | HPGDTSHRMEN1ALDH1A1TP53 | |
| SCHEMBL8503886 | 0.79 | HPGD (0.52) | HPGDTSHRMEN1ALDH1A1TP53 | |
| SCHEMBL9440267 | 0.77 | HPGD (0.54) | HPGDTSHRMEN1ALDH1A1TP53 | |
| SCHEMBL1299701 | 0.75 | HPGD (0.63) | HPGDTSHRMEN1ALDH1A1TP53 | |
| SCHEMBL507935 | 0.74 | HPGD (0.51) | HPGDTSHRMEN1ALDH1A1TP53 | |
| SCHEMBL9440366 | 0.74 | HPGD (0.48) | HPGDTSHRMEN1ALDH1A1TP53 | |
| SCHEMBL19023278 | 0.74 | HPGD (0.47) | HPGDTSHRMEN1ALDH1A1TP53 | |
| SCHEMBL18072 | 0.73 | HPGD (0.46) | HPGDTSHRMEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526488-B1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS | PFIZER (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5326905-A | Benzylphosphonic acid tyrosine kinase inhibitors | PFIZER INC. (US) | 1994-07-05 | — | — | US | disclosed |
| EP-0526488-A1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS. | PFIZER (US) | 1993-02-10 | — | — | EP | disclosed |
| WO-1991015495-A1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |