Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9444449 | 0.97 | KCNH2 (0.57) | KCNH2CYP2D6CYP3A4CYP2C19KDM4E | |
| SCHEMBL9444395 | 0.94 | KCNH2 (0.65) | KCNH2CYP2D6CYP3A4CYP2C19KDM4E | |
| SCHEMBL9444363 | 0.88 | KCNH2 (0.62) | KCNH2CYP2D6CYP3A4CYP2C19KDM4E | |
| SCHEMBL9444414 | 0.85 | KCNH2 (0.62) | KCNH2CYP2D6CYP3A4CYP2C19KDM4E | |
| SCHEMBL9444355 | 0.84 | KCNH2 (0.57) | KCNH2CYP2D6CYP3A4CYP2C19KDM4E | |
| SCHEMBL9444336 | 0.81 | KCNH2 (0.67) | KCNH2CYP2D6CYP3A4CYP2C19KDM4E | |
| SCHEMBL9444370 | 0.81 | KCNH2 (0.63) | KCNH2CYP2D6CYP3A4CYP2C19KDM4E | |
| SCHEMBL9444429 | 0.81 | KCNH2 (0.61) | KCNH2CYP2D6CYP3A4CYP2C19KDM4E | |
| SCHEMBL9444348 | 0.81 | KCNH2 (0.71) | KCNH2CYP2D6CYP3A4CYP2C19KDM4E | |
| SCHEMBL9444344 | 0.80 | KCNH2 (0.61) | KCNH2CYP2D6CYP3A4CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235752-B1 | Piperidine derivative, pharmaceutical composition containing the same and use | EISAI CO LTD (JP) | 1993-11-18 | — | — | EP | disclosed |
| US-5179095-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1993-01-12 | — | — | US | disclosed |
| US-5118689-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4996215-A | Antiarrythmia agents | EISAI CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| US-4876262-A | ANTIARRHYTHMIA AGENTS | EISAI CO., LTD. (JP) | 1989-10-24 | — | — | US | disclosed |
| EP-0235752-A2 | Piperidine derivative, pharmaceutical composition containing the same and use | Eisai Co., Ltd. (JP) | 1987-09-09 | — | — | EP | disclosed |