Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9444364 | 0.99 | KCNH2 (0.60) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9172253 | 0.89 | HTR2A (0.70) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9444369 | 0.89 | KCNH2 (0.57) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9172595 | 0.88 | KCNH2 (0.69) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9444437 | 0.88 | POLB (0.58) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9444492 | 0.88 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9444470 | 0.87 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9444348 | 0.87 | KCNH2 (0.71) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9444349 | 0.84 | KCNH2 (0.62) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9444408 | 0.84 | KMT2A (0.56) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235752-B1 | Piperidine derivative, pharmaceutical composition containing the same and use | EISAI CO LTD (JP) | 1993-11-18 | — | — | EP | disclosed |
| US-5179095-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1993-01-12 | — | — | US | disclosed |
| US-5118689-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4996215-A | Antiarrythmia agents | EISAI CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| US-4876262-A | ANTIARRHYTHMIA AGENTS | EISAI CO., LTD. (JP) | 1989-10-24 | — | — | US | disclosed |
| EP-0235752-A2 | Piperidine derivative, pharmaceutical composition containing the same and use | Eisai Co., Ltd. (JP) | 1987-09-09 | — | — | EP | disclosed |