Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL933040 | 0.92 | BACE1 (0.70) | BACE1KCNH2BACE2 | |
| SCHEMBL6893894 | 0.90 | BACE1 (0.58) | BACE1KCNH2BACE2 | |
| SCHEMBL945742 | 0.84 | BACE1 (0.58) | BACE1KCNH2BACE2 | |
| SCHEMBL945592 | 0.83 | BACE1 (0.61) | BACE1KCNH2BACE2 | |
| SCHEMBL1081534 | 0.82 | BACE1 (0.57) | BACE1KCNH2BACE2 | |
| SCHEMBL931366 | 0.81 | BACE1 (0.46) | BACE1KCNH2BACE2 | |
| SCHEMBL9948840 | 0.75 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL9949092 | 0.75 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL944883 | 0.74 | BACE1 (0.54) | BACE1KCNH2BACE2 | |
| SCHEMBL9949326 | 0.72 | BACE1 (1.00) | BACE1KCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |