Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8498012 | 0.88 | PTGER1 (0.44) | MRGPRX4HPGDPTGER1MAPTACLY | |
| SCHEMBL8370765 | 0.88 | PTGER1 (0.51) | MRGPRX4HPGDPTGER1 | |
| Hydrochloric Acid SCHEMBL8497008 | 0.87 | PTGER1 (0.50) | MRGPRX4HPGDPTGER1 | |
| SCHEMBL8497004 | 0.87 | PTGER1 (0.45) | MRGPRX4HPGDPTGER1ACLY | |
| SCHEMBL8498022 | 0.85 | MRGPRX4 (0.46) | MRGPRX4HPGDPTGER1MAPT | |
| SCHEMBL9452305 | 0.83 | SCN1A (0.42) | LMNAHPGDPTGER1MAPT | |
| SCHEMBL9452284 | 0.83 | MAPT (0.40) | NOTUMCNR1EGFRHPGDPTGER1 | |
| SCHEMBL9452265 | 0.83 | GAA (0.42) | EGFRHPGDPTGER1MAPT | |
| SCHEMBL9452354 | 0.82 | KCNH2 (0.38) | NOTUMHPGDPTGER1MAPTACLY | |
| SCHEMBL9452275 | 0.81 | SRC (0.46) | EGFRERBB2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270309-A | Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders | MERCK SHARP & DOHME LIMITED (GB) | 1993-12-14 | — | — | US | disclosed |
| EP-0303387-B1 | KYNURENIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1993-04-21 | — | — | EP | disclosed |
| EP-0303387-A1 | Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders | MERCK SHARP & DOHME LTD. (GB) | 1989-02-15 | — | — | EP | disclosed |