Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 11/20 | 0.63 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.52 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | TPH1 | P17752 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3428464 | 0.88 | S1PR1 (0.81) | S1PR1S1PR5 | |
| SCHEMBL3426941 | 0.87 | S1PR1 (0.67) | S1PR1S1PR5 | |
| SCHEMBL946556 | 0.85 | S1PR1 (0.79) | S1PR1S1PR5 | |
| SCHEMBL3750089 | 0.85 | S1PR1 (0.56) | S1PR1S1PR5MAPTTP53POLB | |
| SCHEMBL3752419 | 0.84 | S1PR1 (0.82) | S1PR1S1PR5 | |
| SCHEMBL3428745 | 0.84 | S1PR1 (0.63) | S1PR1S1PR5PLAT | |
| SCHEMBL946042 | 0.83 | S1PR1 (0.58) | S1PR1S1PR5HDAC1HDAC8HDAC6 | |
| SCHEMBL3429272 | 0.83 | S1PR1 (0.68) | S1PR1S1PR5 | |
| SCHEMBL3430740 | 0.83 | S1PR1 (0.82) | S1PR1S1PR5 | |
| SCHEMBL947598 | 0.82 | S1PR1 (0.58) | S1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005290-A1 | DISUBSTITUTED OXADIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |