Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 1.00 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.59 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL947343 | 1.00 | S1PR1 (1.00) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL950290 | 0.91 | S1PR1 (0.84) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL2014368 | 0.88 | S1PR1 (0.78) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL2022280 | 0.88 | S1PR1 (0.78) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL2014370 | 0.88 | S1PR1 (0.78) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL946121 | 0.87 | S1PR1 (1.00) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL946661 | 0.87 | S1PR1 (1.00) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL948759 | 0.84 | S1PR1 (0.77) | S1PR1S1PR4S1PR5 | |
| SCHEMBL2018192 | 0.82 | S1PR1 (0.72) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL2017713 | 0.82 | S1PR1 (0.72) | S1PR1S1PR4S1PR5ADORA3S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | claimed |
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |