Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 12/20 | 1.00 |
| ▸ | CNR1 | P21554 | 10/20 | 0.56 |
| ▸ | PNLIP | P16233 | 3/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | DAGLB | Q8NCG7 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.50 |
| ▸ | LPL | P06858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LIPC | P11150 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | FASN | P49327 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.50 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.50 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.50 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132200 | 1.00 | DAGLA (1.00) | DAGLACNR1PNLIPMGLLCNR2 | |
| SCHEMBL9456849 | 1.00 | DAGLA (1.00) | DAGLACNR1PNLIPMGLLCNR2 | |
| SCHEMBL712201 | 1.00 | DAGLA (1.00) | DAGLACNR1PNLIPMGLLCNR2 | |
| SCHEMBL713349 | 1.00 | DAGLA (1.00) | DAGLACNR1PNLIPMGLLCNR2 | |
| SCHEMBL8780224 | 1.00 | DAGLA (1.00) | DAGLACNR1PNLIPMGLLCNR2 | |
| SCHEMBL9262909 | 1.00 | DAGLA (1.00) | DAGLACNR1PNLIPMGLLCNR2 | |
| SCHEMBL1172713 | 1.00 | DAGLA (1.00) | DAGLACNR1PNLIPMGLLCNR2 | |
| SCHEMBL715602 | 1.00 | DAGLA (1.00) | DAGLACNR1PNLIPMGLLCNR2 | |
| SCHEMBL21055846 | 1.00 | DAGLA (1.00) | DAGLACNR1PNLIPMGLLCNR2 | |
| SCHEMBL12083542 | 1.00 | DAGLA (1.00) | DAGLACNR1PNLIPMGLLCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246960-A | Used to treat obesity, hyperlipaemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5175186-A | Inhibits pancreas lepase and useful agent in treatment of obesity, hyperlipemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1992-12-29 | — | — | US | disclosed |
| EP-0185359-B1 | OXETANONE | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-04 | — | — | EP | disclosed |
| US-4931463-A | PANCREAS LIPASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1990-06-05 | — | — | US | disclosed |
| EP-0185359-A2 | Oxetanone | F. HOFFMANN-LA ROCHE AG (CH) | 1986-06-25 | — | — | EP | disclosed |