Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.31 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9457405 | 1.00 | KMT2A (0.35) | KMT2AMEN1GPR84FFAR1ALDH1A1 | |
| SCHEMBL9457326 | 1.00 | KMT2A (0.35) | KMT2AMEN1GPR84FFAR1ALDH1A1 | |
| SCHEMBL9457121 | 1.00 | KMT2A (0.35) | KMT2AMEN1GPR84FFAR1ALDH1A1 | |
| SCHEMBL9457398 | 1.00 | KMT2A (0.35) | KMT2AMEN1GPR84FFAR1ALDH1A1 | |
| SCHEMBL9457330 | 1.00 | KMT2A (0.35) | KMT2AMEN1GPR84FFAR1ALDH1A1 | |
| SCHEMBL9457048 | 0.89 | KMT2A (0.35) | KMT2AMEN1GPR84FFAR1ALDH1A1 | |
| SCHEMBL9457037 | 0.89 | KMT2A (0.35) | KMT2AMEN1GPR84FFAR1ALDH1A1 | |
| SCHEMBL9457001 | 0.89 | KMT2A (0.35) | KMT2AMEN1GPR84FFAR1ALDH1A1 | |
| SCHEMBL9865919 | 0.89 | KMT2A (0.35) | KMT2AMEN1GPR84FFAR1ALDH1A1 | |
| SCHEMBL9457043 | 0.89 | KMT2A (0.35) | KMT2AMEN1GPR84FFAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246960-A | Used to treat obesity, hyperlipaemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5175186-A | Inhibits pancreas lepase and useful agent in treatment of obesity, hyperlipemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1992-12-29 | — | — | US | disclosed |
| US-4931463-A | PANCREAS LIPASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1990-06-05 | — | — | US | disclosed |