Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | CASP3 | P42574 | 2/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458244 | 0.89 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTRAB9ACASP3SENP8 | |
| SCHEMBL10463544 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTRAB9ACASP3SENP8 | |
| SCHEMBL10461285 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTRAB9ACASP3SENP8 | |
| SCHEMBL10459982 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTRAB9ACASP3SENP8 | |
| SCHEMBL10462067 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTRAB9ACASP3SENP8 | |
| SCHEMBL10462207 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTRAB9ACASP3SENP8 | |
| SCHEMBL10462506 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTRAB9ACASP3SENP8 | |
| SCHEMBL10463014 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTRAB9ACASP3SENP8 | |
| SCHEMBL10463092 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTRAB9ACASP3SENP8 | |
| SCHEMBL10462435 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTRAB9ACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5230827-A | DERIVATIVES OF 2,3-DIFLUOROBENZOIC ACID | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-07-27 | — | — | US | claimed |
| US-5230827-A | DERIVATIVES OF 2,3-DIFLUOROBENZOIC ACID | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-07-27 | — | — | US | disclosed |
| EP-0358741-B1 | DERIVATIVES OF 2,3-DIFLUOROBENZOIC ACID | MERCK PATENT GmbH (DE) | 1993-02-10 | — | — | EP | disclosed |
| EP-0358741-A1 | DERIVATIVES OF 2,3-DIFLUOROBENZOIC ACID. | MERCK PATENT GMBH (DE) | 1990-03-21 | — | — | EP | disclosed |
| WO-1989008688-A1 | DERIVATIVES OF 2,3-DIFLUOROBENZOIC ACID | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1989-09-21 | — | — | WO | disclosed |