Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9457528 | 0.88 | MAPT (0.53) | MAPTL3MBTL1LMNAPTGDR2AKR1B1 | |
| SCHEMBL9457636 | 0.88 | MAPT (0.61) | MAPTLMNAPTGDR2AKR1B1CYP3A4 | |
| SCHEMBL9458095 | 0.88 | MAPT (0.55) | MAPTL3MBTL1LMNACYP3A4TSHR | |
| Methane SCHEMBL9457803 | 0.87 | MAPT (0.60) | MAPTLMNAPTGDR2AKR1B1CYP3A4 | |
| SCHEMBL9457497 | 0.82 | MAPT (0.59) | MAPTPTGDR2AKR1B1CYP3A4TSHR | |
| SCHEMBL9458259 | 0.81 | PTGES2 (0.72) | MAPTCYP3A4TSHRHSD17B10MEN1 | |
| SCHEMBL21465486 | 0.80 | MEN1 (0.83) | MAPTLMNAPTGDR2AKR1B1CYP3A4 | |
| SCHEMBL9457612 | 0.79 | MAPT (0.42) | MAPTL3MBTL1LMNACYP3A4TSHR | |
| SCHEMBL9457791 | 0.77 | CYP3A4 (0.58) | MAPTPTGDR2AKR1B1CYP3A4TSHR | |
| SCHEMBL23760017 | 0.77 | MAPT (0.75) | MAPTL3MBTL1LMNAPTGDR2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5225421-A | Leukotriene antagonists; cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1993-07-06 | — | — | US | disclosed |
| EP-0275667-B1 | 3-HETERO-SUBSTITUTED-N-BENZYL-INDOLES | MERCK FROSST CANADA INC. (CA) | 1992-03-18 | — | — | EP | disclosed |
| US-5081138-A | Antiasthmatic, antiallergic, antiinflammatory and cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1992-01-14 | — | — | US | disclosed |
| EP-0275667-A1 | 3-hetero-substituted-N-benzyl-indoles | MERCK FROSST CANADA INC. (CA) | 1988-07-27 | — | — | EP | disclosed |