SCHEMBL9458406

SCHEMBL9458406

C=CCCCc1ccc(C#N)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.50
HSD17B10 Q99714 1/20 0.50
KCNJ1 P48048 1/20 0.46
KCNH2 Q12809 1/20 0.46
LOXL2 Q9Y4K0 2/20 0.45
CYP2A6 P11509 1/20 0.45
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
CYP19A1 P11511 3/20 0.38
DAO P14920 2/20 0.38
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
IDO1 P14902 2/20 0.37
MMP12 P39900 1/20 0.36
MMP13 P45452 1/20 0.36
CA12 O43570 2/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA9 Q16790 2/20 0.36
SNCA P37840 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10341661 0.95 TSHR (0.58) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL2968409 0.88 KCNJ1 (0.48) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL7791266 0.87 MEN1 (0.45) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL7791269 0.87 MEN1 (0.45) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL19599410 0.84 TSHR (0.64) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL29819537 0.83 HDAC1 (0.43) TSHRMAOB
SCHEMBL9457628 0.83 TSHR (0.53) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL7851913 0.83 KCNJ1 (0.44) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL7793250 0.83 MEN1 (0.44) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL7793254 0.83 MEN1 (0.44) TSHRHSD17B10KCNJ1KCNH2LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5238602-A Electrooptical cells HOFFMANN LA ROCHE INC. (US) 1993-08-24 US disclosed
EP-0168683-B1 LIQUID CRYSTALS WITH ALKENYL OR ALKENYLOXY GROUPS F. HOFFMANN-LA ROCHE AG (CH) 1990-11-28 EP disclosed
EP-0167912-B1 LIQUID CRYSTAL MIXTURES CONTAINING COMPOUNDS WITH A 4-ALKENYL OR 2Z-ALKENYL LATERAL CHAIN F. HOFFMANN-LA ROCHE AG (CH) 1990-01-03 EP disclosed
US-4709030-A 4-ALKENYL OR 2Z-ALKENYL POLYPHENYL COMPOUNDS; ELECTRO-OPTICS HOFFMANN-LA ROCHE INC. (US) 1987-11-24 US disclosed
US-4621901-A ELECTROOPTICS HOFFMANN-LA ROCHE INC. (US) 1986-11-11 US disclosed
EP-0168683-A2 Liquid crystals with alkenyl or alkenyloxy groups F. HOFFMANN-LA ROCHE AG (CH) 1986-01-22 EP disclosed
EP-0167912-A2 Liquid crystal mixtures containing compounds with a 4-alkenyl or 2Z-alkenyl lateral chain F. HOFFMANN-LA ROCHE AG (CH) 1986-01-15 EP disclosed