Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MPC2 | O95563 | 2/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196242 | 0.89 | PPARG (0.66) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL9458269 | 0.87 | PPARG (0.52) | PPARGCYP3A4RXRAMAOBFFAR1 | |
| SCHEMBL14519307 | 0.84 | MAOB (0.57) | PPARGCYP3A4RXRAMAOBFFAR1 | |
| SCHEMBL5172074 | 0.82 | PPARG (0.64) | PPARGCYP3A4RXRAMAOBFFAR1 | |
| SCHEMBL2944577 | 0.80 | PPARG (0.80) | PPARGCYP3A4RXRAMAOBFFAR1 | |
| SCHEMBL30640947 | 0.80 | PPARG (0.80) | PPARGCYP3A4RXRAMAOBFFAR1 | |
| SCHEMBL13475125 | 0.80 | PPARG (0.80) | PPARGCYP3A4RXRAMAOBFFAR1 | |
| SCHEMBL12521693 | 0.79 | PPARG (0.64) | PPARGCYP3A4RXRAFFAR1PPARA | |
| Hydrochloric Acid SCHEMBL1162844 | 0.79 | PPARG (0.81) | PPARGCYP3A4RXRAMAOBFFAR1 | |
| SCHEMBL9458054 | 0.79 | MAOB (0.51) | PPARGCYP3A4RXRAMAOBFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5183823-A | PYRIDINE N-OXIDE COMPOUNDS WHICH ARE USEFUL AS HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-02-02 | — | — | US | disclosed |