Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1233429 | 0.88 | KMT2A (0.43) | MAPTKMT2AGAAFAAHCYP1A2 | |
| SCHEMBL4882370 | 0.86 | CNR2 (0.46) | CYP1A2CNR2 | |
| SCHEMBL1233563 | 0.85 | MAPT (0.38) | MAPTKMT2AGAAFAAHCYP1A2 | |
| SCHEMBL1234207 | 0.85 | MAPT (0.45) | MAPTKMT2AGAAFAAHCYP1A2 | |
| SCHEMBL22412805 | 0.84 | MAPT (0.44) | MAPTKMT2AGAAFAAHCYP1A2 | |
| SCHEMBL22412844 | 0.84 | MAPT (0.44) | MAPTKMT2AGAAFAAHCYP1A2 | |
| SCHEMBL1233839 | 0.83 | MAPT (0.40) | MAPTKMT2AGAAFAAHCYP1A2 | |
| SCHEMBL1233748 | 0.82 | NR1H2 (0.41) | MAPTKMT2AGAAFAAHCYP1A2 | |
| SCHEMBL1232533 | 0.82 | KMT2A (0.40) | MAPTKMT2AGAACYP1A2TP53 | |
| SCHEMBL1233460 | 0.80 | CNR2 (0.37) | MAPTKMT2AGAACYP1A2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252593-A | Hypotensive agents, cognition activators | GLAXO GROUP LIMITED (GB) | 1993-10-12 | — | — | US | disclosed |
| EP-0514217-A1 | Antihypertensive benzofuran derivatives carrying 4-pyrazolylmethyl substituents | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |