Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.56 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 2/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30931733 | 0.88 | KDM4E (0.78) | KDM4EALDH1A1HPGDCLK4SMN1; SMN2 | |
| SCHEMBL11346886 | 0.88 | KDM4E (0.78) | KDM4EALDH1A1HPGDCLK4SMN1; SMN2 | |
| SCHEMBL3166111 | 0.87 | KDM4E (0.77) | KDM4EALDH1A1HPGDCLK4SMN1; SMN2 | |
| SCHEMBL29071789 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1HPGDCLK4SMN1; SMN2 | |
| SCHEMBL9468406 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1HPGDCLK4SMN1; SMN2 | |
| SCHEMBL29071790 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1HPGDCLK4SMN1; SMN2 | |
| SCHEMBL3162634 | 0.84 | KDM4E (0.72) | KDM4EALDH1A1HPGDCLK4SMN1; SMN2 | |
| SCHEMBL5804188 | 0.84 | KDM4E (0.71) | KDM4EALDH1A1HPGDCLK4SMN1; SMN2 | |
| SCHEMBL9468711 | 0.84 | KDM4E (0.71) | KDM4EALDH1A1HPGDCLK4SMN1; SMN2 | |
| SCHEMBL30579781 | 0.84 | KDM4E (0.71) | KDM4EALDH1A1HPGDCLK4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114716442-B | Synthesis method of 5, 6-unsubstituted pyrazolo [1,5-a ] pyrimidine compound | 重庆医科大学 | 2023-09-19 | — | — | CN | claimed |
| CN-114716442-A | Synthesis method of 5, 6-unsubstituted pyrazolo [1,5-a ] pyrimidine compound | 重庆医科大学 | 2022-07-08 | — | — | CN | claimed |
| CN-114716442-B | Synthesis method of 5, 6-unsubstituted pyrazolo [1,5-a ] pyrimidine compound | 重庆医科大学 | 2023-09-19 | — | — | CN | disclosed |
| CN-114716442-A | Synthesis method of 5, 6-unsubstituted pyrazolo [1,5-a ] pyrimidine compound | 重庆医科大学 | 2022-07-08 | — | — | CN | disclosed |
| US-5219857-A | Method of treating cognitive and related neural behavioral problems | AMERICAN CYANAMID COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| US-5126340-A | Antidepressants | AMERICAN CYANAMID COMPANY (US) | 1992-06-30 | — | — | US | disclosed |
| US-4963553-A | TREATING COGNITIVE AND NEURAL BEHAVIORAL PROBLEMS IN MAMMALS | AMERICAN CYANAMID CO. (US) | 1990-10-16 | — | — | US | disclosed |
| US-4916137-A | 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders | AMERICAN CYANAMID COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |
| US-4236005-A | ANTIANXIETY | AMERICAN CYANAMID COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| US-4178449-A | Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1979-12-11 | — | — | US | disclosed |