Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13962860 | 0.82 | TRPV1 (0.64) | NPC1TSHRRAB9AKDM4EMAPT | |
| SCHEMBL14284354 | 0.81 | TLR7 (0.67) | NPC1TSHRRAB9AKDM4EMAPT | |
| SCHEMBL6948731 | 0.80 | BACE1 (0.53) | NPC1TSHRRAB9AKDM4EMAPT | |
| SCHEMBL3175503 | 0.79 | GRM4 (0.72) | NPC1TSHRRAB9AKDM4EMAPT | |
| SCHEMBL18070914 | 0.75 | MAPK1 (0.56) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL6595078 | 0.75 | MAPT (0.53) | NPC1TSHRRAB9AKDM4EMAPT | |
| SCHEMBL4020308 | 0.75 | KDR (0.71) | NPC1TSHRRAB9AKDM4EMAPT | |
| SCHEMBL5291484 | 0.74 | KDM4E (0.58) | NPC1TSHRRAB9AKDM4EMAPT | |
| SCHEMBL6104350 | 0.74 | KDR (0.57) | NPC1TSHRRAB9AKDM4EMAPT | |
| SCHEMBL427598 | 0.73 | KDR (0.68) | KDRNAMPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0347698-A1 | Heterobicyclic compounds having antiinflammatory activity | SCHERING CORPORATION (US) | 1989-12-27 | — | — | EP | disclosed |