Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469793 | 1.00 | CYP4F2 (0.37) | CYP4F2CYP4A11ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL27542500 | 0.91 | CYP4F2 (0.42) | CYP4F2CYP4A11 | |
| SCHEMBL10691795 | 0.91 | CYP4F2 (0.42) | CYP4F2CYP4A11ALDH1A1L3MBTL1MAPT | |
| SCHEMBL10691801 | 0.91 | CYP4F2 (0.42) | CYP4F2CYP4A11ALDH1A1L3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL27539970 | 0.89 | CYP4F2 (0.41) | CYP4F2CYP4A11 | |
| SCHEMBL9469539 | 0.82 | CYP4F2 (0.38) | CYP4F2CYP4A11ALDH1A1KDM4EMEN1 | |
| SCHEMBL9469538 | 0.82 | CYP4F2 (0.38) | CYP4F2CYP4A11ALDH1A1KDM4EMEN1 | |
| SCHEMBL13827636 | 0.77 | CYP4F2 (0.56) | CYP4F2CYP4A11ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL9469577 | 0.74 | CYP4F2 (0.34) | CYP4F2CYP4A11ALDH1A1KDM4EMEN1 | |
| SCHEMBL14394093 | 0.74 | CYP4F2 (0.41) | CYP4F2CYP4A11ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |