Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 13/20 | 0.80 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | PPARD | Q03181 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469891 | 1.00 | MME (0.80) | MMEPPARGPPARDKDM4EALDH1A1 | |
| SCHEMBL9470376 | 0.94 | MME (0.88) | MMEPPARGPPARDKDM4EALDH1A1 | |
| Candoxatril SCHEMBL14660450 | 0.92 | MME (0.95) | MMEPPARGPPARDKDM4EPPARA | |
| SCHEMBL9469547 | 0.90 | MME (0.77) | MMEPPARGPPARDKDM4EALDH1A1 | |
| SCHEMBL9469545 | 0.90 | MME (0.77) | MMEPPARGPPARDKDM4EALDH1A1 | |
| Candoxatril SCHEMBL1649937 | 0.89 | MME (1.00) | MMEPPARGPPARDKDM4EPPARA | |
| Candoxatril SCHEMBL121666 | 0.89 | MME (1.00) | MMEPPARGPPARDKDM4EPPARA | |
| Candoxatril SCHEMBL5601069 | 0.89 | MME (1.00) | MMEPPARGPPARDKDM4EPPARA | |
| Candoxatril SCHEMBL29494166 | 0.89 | MME (1.00) | MMEPPARGPPARDKDM4EPPARA | |
| Candoxatril SCHEMBL392920 | 0.89 | MME (1.00) | MMEPPARGPPARDKDM4EPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | claimed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | claimed |
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |