Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 10/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9470572 | 1.00 | MME (0.46) | MMEMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL7291524 | 0.89 | MME (0.51) | MMEMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL7302140 | 0.89 | MME (0.51) | MMEMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL9470040 | 0.87 | MME (0.49) | MMEMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL9470044 | 0.87 | MME (0.49) | MMEMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL9469801 | 0.86 | MME (0.46) | MMEMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL9480715 | 0.86 | MME (0.48) | MMEMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL9469798 | 0.86 | MME (0.46) | MMEMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL9480729 | 0.86 | MME (0.48) | MMEMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL9470264 | 0.84 | MME (0.47) | MMEMEN1ALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |