Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9474033 | 1.00 | TP53 (0.46) | TP53POLBACE | |
| SCHEMBL9475000 | 0.92 | TP53 (0.46) | TP53POLB | |
| SCHEMBL9472962 | 0.87 | TP53 (0.45) | TP53POLB | |
| SCHEMBL9473359 | 0.84 | TP53 (0.44) | TP53ACE | |
| SCHEMBL7056869 | 0.83 | TP53 (0.45) | TP53 | |
| SCHEMBL8957103 | 0.82 | TP53 (0.44) | TP53POLBACE | |
| SCHEMBL8957111 | 0.82 | TP53 (0.44) | TP53POLBACE | |
| SCHEMBL7054174 | 0.81 | TP53 (0.48) | TP53 | |
| SCHEMBL8957074 | 0.81 | TP53 (0.45) | TP53 | |
| SCHEMBL8957081 | 0.81 | TP53 (0.45) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0437103-A2 | Substituted 5-(alkyl)carboxamide imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-17 | — | — | EP | claimed |
| US-5234917-A | Hypotensive agent, treatment of renal failure or glaucoma | SMITHKLINE BEECHAM CORPORATION | 1993-08-10 | — | — | US | disclosed |
| EP-0437103-A2 | Substituted 5-(alkyl)carboxamide imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-17 | — | — | EP | disclosed |