Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 2-Chloropyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CCR1 | P32246 | 2/20 | 0.31 |
| ▸ | CCR5 | P51681 | 2/20 | 0.31 |
| ▸ | CCR8 | P51685 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.31 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Chloropyridine SCHEMBL9475922 | 0.89 | TDP1 (0.73) | TDP1TRPA1KDM4EALDH1A1GAA | |
| 2-Chloropyridine SCHEMBL27270390 | 0.78 | — | — | |
| 2-Chloropyridine SCHEMBL9476183 | 0.77 | TDP1 (0.50) | TDP1KDM4ELMNACYP1A2SMN1; SMN2 | |
| 2-Chloropyridine SCHEMBL27450572 | 0.76 | — | — | |
| 2-Chloropyridine SCHEMBL9366854 | 0.76 | — | — | |
| 2-Chloropyridine SCHEMBL16637 | 0.76 | — | — | |
| 2-Chloropyridine SCHEMBL29402311 | 0.76 | — | — | |
| 2-Chloropyridine SCHEMBL10690176 | 0.76 | TDP1 (1.00) | TDP1TRPA1KDM4EALDH1A1LMNA | |
| 2-Chloropyridine SCHEMBL28283275 | 0.76 | TDP1 (1.00) | TDP1TRPA1KDM4EALDH1A1LMNA | |
| 2-Chloropyridine SCHEMBL11389784 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268479-A | Reacting phosphine with a halogen compound | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-07 | — | — | US | disclosed |