Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | ATM | Q13315 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.70 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21332627 | 0.99 | MAPT (0.70) | MAPTGAAATMCYP1A2CYP2D6 | |
| SCHEMBL27878984 | 0.90 | MAPT (0.71) | MAPTGAAATMCYP1A2CYP2D6 | |
| SCHEMBL2011014 | 0.90 | CYP1A2 (0.67) | MAPTGAAATMCYP1A2CYP2D6 | |
| SCHEMBL21332762 | 0.88 | MAPT (0.70) | MAPTGAAATMCYP1A2CYP2D6 | |
| SCHEMBL30115291 | 0.88 | MAPT (0.70) | MAPTGAAATMCYP1A2CYP2D6 | |
| SCHEMBL4751730 | 0.88 | MAPT (0.70) | MAPTGAAATMCYP1A2CYP2D6 | |
| SCHEMBL21346925 | 0.86 | CYP1A2 (0.66) | MAPTGAAATMCYP1A2CYP2D6 | |
| SCHEMBL9481225 | 0.86 | MAPT (0.67) | MAPTGAAATMCYP1A2CYP2D6 | |
| SCHEMBL21346889 | 0.85 | MAPT (0.65) | MAPTGAAATMCYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL9481217 | 0.85 | GAA (0.65) | MAPTGAAATMCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102775389-B | Preparation method of N-substituted-4-(7-chloro-quinoline -4-amino)-benzamide derivatives, and application thereof | UNIV HUAQIAO | 2014-12-17 | — | — | CN | claimed |
| CN-104030980-A | N-(3-methoxyl-4-chlorphenyl)-4-[(7-chloro-4-quinoline) amino] benzamide, preparation and application thereof | UNIV HUAQIAO | 2014-09-10 | — | — | CN | claimed |
| CN-103724260-A | Benzamide derivative and preparation method and application thereof | UNIV HUAQIAO | 2014-04-16 | — | — | CN | claimed |
| WO-2019173482-A1 | 4-AMINOQUINOLINE COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-09-12 | — | — | WO | disclosed |
| CN-102775389-B | Preparation method of N-substituted-4-(7-chloro-quinoline -4-amino)-benzamide derivatives, and application thereof | UNIV HUAQIAO | 2014-12-17 | — | — | CN | disclosed |
| CN-102775389-B | Preparation method of N-substituted-4-(7-chloro-quinoline -4-amino)-benzamide derivatives, and application thereof | UNIV HUAQIAO | 2014-12-17 | — | — | CN | disclosed |
| CN-104030980-A | N-(3-methoxyl-4-chlorphenyl)-4-[(7-chloro-4-quinoline) amino] benzamide, preparation and application thereof | UNIV HUAQIAO | 2014-09-10 | — | — | CN | disclosed |
| CN-103724260-A | Benzamide derivative and preparation method and application thereof | UNIV HUAQIAO | 2014-04-16 | — | — | CN | disclosed |
| CN-102775389-A | Preparation method of N-substituted-4-(7-chloro-quinoline -4-amino)-benzamide derivatives, and application thereof | UNIV HUAQIAO | 2012-11-14 | — | — | CN | disclosed |
| US-5216165-A | N-substituted aminoquinolines as analgesic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-06-01 | — | — | US | disclosed |
| US-4166853-A | Antihypertensive 7-trifluoromethyl-4-aminoquinolones | THE UPJOHN COMPANY (US) | 1979-09-04 | — | — | US | disclosed |