SCHEMBL9480938

SCHEMBL9480938

CCCCCCCCCCCOc1ccc([N+](=O)[O-])cc1C=O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 6/20 0.57
CYSLTR2 Q9NS75 1/20 0.53
CYSLTR1 Q9Y271 1/20 0.53
MAPT P10636 5/20 0.49
ALDH1A1 P00352 3/20 0.49
LMNA P02545 3/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
KMT2A Q03164 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
ERN1 O75460 1/20 0.48
CNR1 P21554 1/20 0.46
ACHE P22303 1/20 0.46
CNR2 P34972 1/20 0.46
HPGD P15428 2/20 0.45
RAB9A P51151 2/20 0.45
CYP2D6 P10635 2/20 0.45
NPC1 O15118 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28825735 0.94 MAPT (0.55) CYP19A1CYSLTR2CYSLTR1MAPTALDH1A1
SCHEMBL31327257 0.94 MAPT (0.55) CYP19A1CYSLTR2CYSLTR1MAPTALDH1A1
SCHEMBL9471932 0.90 CYP19A1 (0.59) CYP19A1CYSLTR2CYSLTR1MAPTALDH1A1
SCHEMBL215546 0.90 CYP19A1 (0.54) CYP19A1MAPTALDH1A1LMNASMN1; SMN2
SCHEMBL22502367 0.89 CYP19A1 (0.57) CYP19A1CYSLTR2CYSLTR1MAPTALDH1A1
SCHEMBL9825468 0.86 MAPT (0.51) CYP19A1MAPTALDH1A1LMNASMN1; SMN2
SCHEMBL9127581 0.85 CYP19A1 (0.66) CYP19A1CYSLTR2CYSLTR1MAPTALDH1A1
SCHEMBL30292299 0.85 CYP19A1 (0.66) CYP19A1CYSLTR2CYSLTR1MAPTALDH1A1
SCHEMBL4998777 0.85 MAPT (0.56) CYP19A1MAPTALDH1A1LMNASMN1; SMN2
SCHEMBL9165752 0.85 CYP19A1 (0.66) CYP19A1CYSLTR2CYSLTR1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5208353-A Intermediates for preparing epoxy esters SMITHKLINE BEECHAM CORP. (US) 1993-05-04 US disclosed
US-5110959-A PROCESS FOR PREPARATION OF EPOXY ESTERS AND INTERMEDIATES PREPARED THEREBY SMITHKLINE BECKMAN CORP. (US) 1992-05-05 US disclosed
EP-0403252-A2 Process for preparation of epoxy esters and intermediates prepared thereby SMITHKLINE BEECHAM CORPORATION (US) 1990-12-19 EP disclosed
US-4871771-A PHENYL SUBSTITUTED-DITHIA-ALKANEDIOIC ACIDS SMITHKLINE BECKMAN CORPORATION (US) 1989-10-03 US disclosed
EP-0327306-A2 Leukotriene B4 antagonists SMITHKLINE BEECHAM CORPORATION (US) 1989-08-09 EP disclosed